Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

The concentration-dependence of the diffusion and sedimentation coefficients (k(D) and k(s), respectively) of a protein can be used to determine the second virial coefficient (B(2)), a parameter valuable in predicting protein-protein interactions. Accurate measurement of B(2) under physiologically a...

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Bibliographic Details
Main Authors: Saluja, Atul, Fesinmeyer, R. Matthew, Hogan, Sabine, Brems, David N., Gokarn, Yatin R.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955502/
https://ncbi.nlm.nih.gov/pubmed/20959107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.020
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