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Allosteric inhibition of complement function by a staphylococcal immune evasion protein

The complement system is a major target of immune evasion by Staphylococcus aureus. Although many evasion proteins have been described, little is known about their molecular mechanisms of action. Here we demonstrate that the extracellular fibrinogen-binding protein (Efb) from S. aureus acts as an al...

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Hlavní autoři: Chen, Hui, Ricklin, Daniel, Hammel, Michal, Garcia, Brandon L., McWhorter, William J., Sfyroera, Georgia, Wu, You-Qiang, Tzekou, Apostolia, Li, Sheng, Geisbrecht, Brian V., Woods, Virgil L., Lambris, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955122/
https://ncbi.nlm.nih.gov/pubmed/20876141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003750107
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