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Molecular morphology and toxicity of cytoplasmic prion protein aggregates in neuronal and non-neuronal cells
Recent studies have revealed that accumulation of prion protein (PrP) in the cytoplasm results in the production of aggregates that are insoluble in non-ionic detergents and partially resistant to proteinase K. Transgenic mice expressing PrP in the cytoplasm develop severe ataxia with cerebellar deg...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954960/ https://ncbi.nlm.nih.gov/pubmed/16696854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2006.03837.x |
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