Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice

Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes and obesity. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mediates intracellular steroid exposure to mouse liver GR by prereceptor reactivation...

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Main Authors: Liu, Yanjun, Nakagawa, Yuichi, Wang, Ying, Liu, Limei, Du, Hongwei, Wang, Wei, Ren, Xiuhai, Lutfy, Kabirullah, Friedman, Theodore C
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954685/
https://ncbi.nlm.nih.gov/pubmed/18524870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JME-08-0004
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