Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP.

Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine. MBP has been localized on damaged helminths and tissues in hypersensitivity diseases including bronchial asthma. The MBP cDNA indicates that MBP is...

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Publicat a:	J Clin Invest
Autors principals:	Barker, R L, Gundel, R H, Gleich, G J, Checkel, J L, Loegering, D A, Pease, L R, Hamann, K J
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1991
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295464/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1715886/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115379
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