The STC2–PAPP-A–IGFBP4–IGF1 axis and its associations to mortality and CVD in T2D
Objective: Physiologically, pregnancy-associated plasma protein-A (PAPP-A) serves to liberate bound IGF1 by enzymatic cleavage of IGF-binding proteins (IGFBPs), IGFBP4 in particular. Clinically, PAPP-A has been linked to cardiovascular disease (CVD). Stanniocalcin-2 (STC2) is a natural inhibitor...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Bioscientifica
2023-02-01
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| coleção: | Endocrine Connections |
| Assuntos: | |
| Acesso em linha: | https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0451.xml |
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