DHT Selectively Reverses Smad3-Mediated/TGF-β-Induced Responses through Transcriptional Down-Regulation of Smad3 in Prostate Epithelial Cells

Androgens suppress TGF-β responses in the prostate through mechanisms that are not fully explored. We have recently reported that 5α-dihydrotestosterone (DHT) suppresses the ability of TGF-β to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such s...

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Hauptverfasser: Song, Kyung, Wang, Hui, Krebs, Tracy L., Wang, Bingcheng, Kelley, Thomas J., Danielpour, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954637/
https://ncbi.nlm.nih.gov/pubmed/20739403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0165
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