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Rb/E2F4 and Smad2/3 Link Survivin to TGF-β-induced Apoptosis and Tumor Progression
Survivin is a prosurvival protein overexpressed in many cancers through mechanisms that remain poorly explored, and is implicated in control of tumor progression and resistance to cancer chemotherapeutics. Here we report a critical role for survivin in the induction of apoptosis by TGF-β. We show th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762862/ https://ncbi.nlm.nih.gov/pubmed/18504435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.165 |
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