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Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation
Insulin-like growth factor-I inhibits transforming growth factor-β (TGF-β) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt-dependent pathway. Here we provide the first report that the kinase activity of Akt is necessary for its ability to suppress many...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356360/ https://ncbi.nlm.nih.gov/pubmed/16362038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600917 |
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