Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice

PURPOSE: Cytidine drugs, such as gemcitabine, undergo rapid catabolism and inactivation by cytidine deaminase (CD). 3,4,5,6-tetrahydrouridine (THU), a potent CD inhibitor, has been applied preclinically and clinically as a modulator of cytidine analogue metabolism. However, THU is only 20% orally bi...

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Autors principals: Beumer, Jan H., Eiseman, Julie L., Gilbert, Judith A., Holleran, Julianne L., Yellow-Duke, Archibong E., Clausen, Dana M., D’Argenio, David Z., Ames, Matthew M., Hershberger, Pamela A., Parise, Robert A., Bai, Lihua, Covey, Joseph M., Egorin, Merrill J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954253/
https://ncbi.nlm.nih.gov/pubmed/20443002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1337-6
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