Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.

Specific mutations in the UL97 region of human cytomegalovirus (HCMV) have been found to confer resistance to laboratory-adapted strains subjected to ganciclovir selection. In this study, mutations in the UL97 region of HCMV isolates obtained from patients receiving ganciclovir therapy were examined...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Wolf, D G, Smith, I L, Lee, D J, Freeman, W R, Flores-Aguilar, M, Spector, S A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7814623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117648
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