Endoplasmic Reticulum Stress Mediates Radiation-Induced Autophagy via PERK-eIF2α in Caspase-3/7 Deficient Cells

Since apoptosis defects limit efficacy of anti-cancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the me...

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Autores principales: Kim, Kwang Woon, Moretti, Luigi, Mitchell, Lauren R., Jung, Dae Kwang, Lu, Bo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953962/
https://ncbi.nlm.nih.gov/pubmed/20348950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.74
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