Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton

The short actin filaments in the red blood cell (RBC) membrane skeleton are capped at their pointed ends by tropomodulin 1 (Tmod1) and coated with tropomyosin (TM) along their length. Tmod1-TM control of actin filament length is hypothesized to regulate spectrin-actin lattice organization and membra...

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Autors principals: Moyer, Jeannette D., Nowak, Roberta B., Kim, Nancy E., Larkin, Sandra K., Peters, Luanne L., Hartwig, John, Kuypers, Frans A., Fowler, Velia M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953891/
https://ncbi.nlm.nih.gov/pubmed/20585041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-268458
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