Deletion of the RNA-binding proteins Zfp36l1 and Zfp36l2 leads to perturbed thymic development and T-lymphoblastic leukaemia

ZFP36L1 and ZFP36L2 are RNA-binding proteins (RBPs) which interact with AU-rich elements in the 3'UTR of mRNA, leading to mRNA degradation and translational repression. Mice lacking ZFP36L1 and ZFP36L2 during thymopoiesis develop a Notch1-dependent T cell acute lymphoblastic leukaemia (T-ALL)....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hodson, Daniel J., Janas, Michelle L., Galloway, Alison, Bell, Sarah E., Andrews, Simon, Li, Cheuk M., Pannell, Richard, Siebel, Christian W., MacDonald, H. Robson, De Keersmaecker, Kim, Ferrando, Adolfo A., Grutz, Gerald, Turner, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953641/
https://ncbi.nlm.nih.gov/pubmed/20622884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1901
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados