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The RNA-binding proteins Zfp36l1 and Zfp36l2 enforce the thymic β-selection checkpoint by limiting DNA damage response signaling and cell cycle progression

The RNA binding proteins Zfp36l1 and Zfp36l2 act redundantly to enforce the β-selection checkpoint during thymopoiesis, yet their molecular targets remain largely unknown. Here, we identify these targets on a genome wide scale in primary mouse thymocytes and show that Zfp36l1/l2 regulate DNA damage...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Vogel, Katharina U., Bell, Lewis S., Galloway, Alison, Ahlfors, Helena, Turner, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027918/
https://ncbi.nlm.nih.gov/pubmed/27566829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600854
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