A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions

The DNA glycosylase MutY homologue (MYH or MUTYH) removes adenines misincorporated opposite 8-oxoguanine as part of the base excision repair pathway. Importantly, defects in human MYH (hMYH) activity cause the inherited colorectal cancer syndrome, MYH-associated polyposis (MAP). A key feature of MYH...

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Detalhes bibliográficos
Main Authors: Luncsford, Paz J., Chang, Dau-Yin, Shi, Guoli, Bernstein, Jade, Madabushi, Amrita, Patterson, Dimeka N., Lu, A-Lien, Toth, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953589/
https://ncbi.nlm.nih.gov/pubmed/20816984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.08.045
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