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Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity

BACKGROUND: Escherichia coli MutY (EcMutY) reduces mutagenesis by removing adenines paired with guanines or 7,8-dihydro-8-oxo-guanines (8-oxoG). V45 and Q182 of EcMutY are considered to be the key determinants of adenine specificity. Both residues are spatially close to each other in the active site...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chang, Po-Wen, Madabushi, Amrita, Lu, A-Lien
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714593/
https://ncbi.nlm.nih.gov/pubmed/19523222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-10-19
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