Design of a Potent d-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance

The HIV gp41 N-trimer pocket region is an ideal viral target because it is extracellular, highly conserved, and essential for viral entry. Here, we report on the design of a pocket-specific d-peptide, PIE12-trimer, that is extraordinarily elusive to resistance and characterize its inhibitory and str...

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Hlavní autoři: Welch, Brett D., Francis, J. Nicholas, Redman, Joseph S., Paul, Suparna, Weinstock, Matthew T., Reeves, Jacqueline D., Lie, Yolanda S., Whitby, Frank G., Eckert, Debra M., Hill, Christopher P., Root, Michael J., Kay, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953169/
https://ncbi.nlm.nih.gov/pubmed/20719956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01339-10
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