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Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan-Independent Route of Entry

The dependence of viruses on the host cell to complete their replicative cycle renders cellular functions potential targets for novel antivirals. We screened a panel of broadly acting cellular ion channel inhibitors for activity against human cytomegalovirus (HCMV) and identified the voltage-gated c...

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Pubblicato in:J Virol
Autori principali: Murray, M. J., Bonilla-Medrano, N. I., Lee, Q. L., Oxenford, S. J., Angell, R., Depledge, D. P., Reeves, M. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081914/
https://ncbi.nlm.nih.gov/pubmed/31941787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02012-19
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