pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, w...

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Dettagli Bibliografici
Autori principali: Witkowski, Benoit, Iriart, Xavier, Soh, Patrice Njomnang, Menard, Sandie, Alvarez, Muriel, Naneix-Laroche, Veronique, Marchou, Bruno, Magnaval, Jean-François, Benoit-Vical, Françoise, Berry, Antoine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Case Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953132/
https://ncbi.nlm.nih.gov/pubmed/20668121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01057-10
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