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12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation

Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in ani...

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Autors principals: Lindley, Alexa R., Crapster-Pregont, Margaret, Liu, Yanjun, Kuperman, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952968/
https://ncbi.nlm.nih.gov/pubmed/20953328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/727305
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