Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation

Epigenetic changes have been implicated in the pathogenesis of asthma. We sought to determine if IL13, a key cytokine in airway inflammation and remodeling, induced epigenetic DNA methylation and miRNAs expression changes in the airways in conjunction with its transcriptional gene regulation. Induci...

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Autores principales: Ooi, Aik T, Ram, Sonal, Kuo, Alan, Gilbert, Jennifer L, Yan, Weihong, Pellegrini, Matteo, Nickerson, Derek W, Chatila, Talal A, Gomperts, Brigitte N
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353532/
https://ncbi.nlm.nih.gov/pubmed/22611474
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