The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

Background. Bacterial flagellin triggers inflammation in mammalian cells via Toll-like receptor (TLR) 5. Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). However, PI3K has been reported to be either pro- or anti-inflamma...

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Bibliographic Details
Main Authors: Ivison, Sabine M., Khan, Mohammed A. S., Graham, Nicholas R., Shobab, Leila A., Yao, Yu, Kifayet, Arnawaz, Sly, Laura M., Steiner, Theodore S.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952946/
https://ncbi.nlm.nih.gov/pubmed/20953381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/652098
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