The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized the DNA binding and cell-free transcription ability of wild-type SOX9 and a dimerization domain SOX9 mutant. Whereas...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Coustry, Françoise, Oh, Chun-do, Hattori, Takako, Maity, Sankar N., de Crombrugghe, Benoit, Yasuda, Hideyo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952863/
https://ncbi.nlm.nih.gov/pubmed/20484372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq417
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky