The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized the DNA binding and cell-free transcription ability of wild-type SOX9 and a dimerization domain SOX9 mutant. Whereas...

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Bibliografiske detaljer
Main Authors: Coustry, Françoise, Oh, Chun-do, Hattori, Takako, Maity, Sankar N., de Crombrugghe, Benoit, Yasuda, Hideyo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952863/
https://ncbi.nlm.nih.gov/pubmed/20484372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq417
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