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The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template
Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized the DNA binding and cell-free transcription ability of wild-type SOX9 and a dimerization domain SOX9 mutant. Whereas...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952863/ https://ncbi.nlm.nih.gov/pubmed/20484372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq417 |
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