Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase

Selective inhibition of the neuronal isoform of nitric oxide synthase (nNOS) over endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) has become a promising strategy for the discovery of new therapeutic agents for neurodegenerative diseases. However, because of the hi...

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Main Authors: Xue, Fengtian, Li, Huiying, Fang, Jianguo, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952696/
https://ncbi.nlm.nih.gov/pubmed/20833542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.096
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