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Hyper IgM syndrome associated with defective CD40-mediated B cell activation.
Recent studies show that most patients with X-linked hyper IgM syndrome have defects in the gene for CD40 ligand. We evaluated 17 unrelated males suspected of having X-linked hyper IgM syndrome. Activated T cells from 13 of the 17 patients failed to bind a soluble CD40 construct. In these patients,...
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| Udgivet i: | J Clin Invest |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
1994
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7523449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117476 |
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