Hyper IgM syndrome associated with defective CD40-mediated B cell activation.

Recent studies show that most patients with X-linked hyper IgM syndrome have defects in the gene for CD40 ligand. We evaluated 17 unrelated males suspected of having X-linked hyper IgM syndrome. Activated T cells from 13 of the 17 patients failed to bind a soluble CD40 construct. In these patients,...

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Autores principales: Conley, M E, Larché, M, Bonagura, V R, Lawton, A R, Buckley, R H, Fu, S M, Coustan-Smith, E, Herrod, H G, Campana, D
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC295267/
https://ncbi.nlm.nih.gov/pubmed/7523449
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