Hyper IgM syndrome associated with defective CD40-mediated B cell activation.

Recent studies show that most patients with X-linked hyper IgM syndrome have defects in the gene for CD40 ligand. We evaluated 17 unrelated males suspected of having X-linked hyper IgM syndrome. Activated T cells from 13 of the 17 patients failed to bind a soluble CD40 construct. In these patients,...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Conley, M E, Larché, M, Bonagura, V R, Lawton, A R, Buckley, R H, Fu, S M, Coustan-Smith, E, Herrod, H G, Campana, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7523449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117476
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