Molecular Analysis of Non-Small Cell Lung Cancer (NSCLC) Identifies Subsets with Different Sensitivity to Insulin like Growth Factor I Receptor (IGF-IR) Inhibition

PURPOSE: Identify molecular determinants of sensitivity of NSCLC to anti-insulin like growth factor receptor (IGF-IR) therapy. EXPERIMENTAL DESIGN: 216 tumor samples were investigated. 165 consisted of retrospective analyses of banked tissue and an additional 51 were from patients enrolled in a phas...

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Main Authors: Gualberto, Antonio, Dolled-Filhart, Marisa, Gustavson, Mark, Christiansen, Jason, Wang, Yu-Fen, Hixon, Mary L., Reynolds, Jennifer, McDonald, Sandra, Ang, Agnes, Rimm, David L., Langer, Corey J., Blakely, Johnetta, Garland, Linda, Paz-Ares, Luis G., Karp, Daniel D., Lee, Adrian V.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952544/
https://ncbi.nlm.nih.gov/pubmed/20670944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0089
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