IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Li, Heming, Batth, Izhar Singh, Qu, Xiujuan, Xu, Ling, Song, Na, Wang, Ruoyu, Liu, Yunpeng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282886/
https://ncbi.nlm.nih.gov/pubmed/28137302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0576-5
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