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Unlike thyrotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices.

The effects of thyroid-stimulating antibodies (TSAb) and of thyrotropin (TSH) were compared, on the generation of cyclic AMP and inositol phosphates (InsP), in human thyroid slices incubated in vitro, and on the Rapoport cyclic AMP bioassay. The TSAb positive sera were obtained from 19 patients with...

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Udgivet i:J Clin Invest
Principais autores: Laurent, E, Van Sande, J, Ludgate, M, Corvilain, B, Rocmans, P, Dumont, J E, Mockel, J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295251/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1673689/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115178
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