PI3K/PTEN/AKT/mTOR Pathway Genetic Variation Predicts Toxicity and Distant Progression in Lung Cancer Patients Receiving Platinum-based Chemotherapy

Non-small cell lung cancer (NSCLC) is still the leading cause of cancer-related deaths. The effect of the PI3K/PTEN/AKT/mTOR signaling pathway on cancer treatment, including NSCLC, has been well documented. In this study, we analyzed associations between genetic variations within this pathway and cl...

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Bibliographic Details
Main Authors:	Pu, Xia, Hildebrandt, Michelle A.T., Lu, Charles, Lin, Jie, Stewart, David J., Ye, Yuanqing, Gu, Jian, Spitz, Margaret R., Wu, Xifeng
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2952281/ https://ncbi.nlm.nih.gov/pubmed/20447721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2010.04.008
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PI3K/PTEN/AKT/mTOR Pathway Genetic Variation Predicts Toxicity and Distant Progression in Lung Cancer Patients Receiving Platinum-based Chemotherapy

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