Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway Are Associated With Clinical Outcomes in Esophageal Cancer Patients Treated With Chemoradiotherapy

PURPOSE: The phosphoinositide-3-kinase (PI3K), phosphatase and tensin homolog (PTEN), v-akt murine thymoma viral oncogene homolog (AKT), and mammalian target of rapamycin (mTOR) signaling pathway has been implicated in resistance to several chemotherapeutic agents. In this retrospective study, we de...

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Detalhes bibliográficos
Main Authors: Hildebrandt, Michelle A.T., Yang, Hushan, Hung, Mien-Chie, Izzo, Julie G., Huang, Maosheng, Lin, Jie, Ajani, Jaffer A., Wu, Xifeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738430/
https://ncbi.nlm.nih.gov/pubmed/19164214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.17.6297
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