Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

Distant metastasis is the primary failure pattern of nasopharyngeal carcinoma(NPC) in intensity-modulated radiation therapy(IMRT) era. This study was conducted to find the impact of genetic variations in the phosphatidylinositol 3-kinase(PI3K)/phosphatase and tensin homologue(PTEN)/v-akt murine thym...

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Vydáno v:Sci Rep
Hlavní autoři: Guo, Qiaojuan, Lu, Tianzhu, Chen, Yan, Su, Ying, Zheng, Yuhong, Chen, Zeng, Chen, Chao, Lin, Shaojun, Pan, Jianji, Yuan, Xianglin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120316/
https://ncbi.nlm.nih.gov/pubmed/27876891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37576
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