Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain

Although the N terminus of the prion protein (PrP(C)) has been shown to directly associate with lipid membranes, the precise determinants, biophysical basis, and functional implications of such binding, particularly in relation to endogenously occurring fragments, are unresolved. To better understan...

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Detalhes bibliográficos
Main Authors: Boland, Martin P., Hatty, Claire R., Separovic, Frances, Hill, Andrew F., Tew, Deborah J., Barnham, Kevin J., Haigh, Cathryn L., James, Michael, Masters, Colin L., Collins, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952229/
https://ncbi.nlm.nih.gov/pubmed/20679345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123398
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