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Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression
DNA polymerase δ (pol δ) is one of the two main replicative polymerases in eukaryotes; it synthesizes the lagging DNA strand and also functions in DNA repair. In previous work, we demonstrated that heterozygous expression of the pol δ L604G variant in mice results in normal life span and no apparent...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952227/ https://ncbi.nlm.nih.gov/pubmed/20628184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147017 |
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