Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression

DNA polymerase δ (pol δ) is one of the two main replicative polymerases in eukaryotes; it synthesizes the lagging DNA strand and also functions in DNA repair. In previous work, we demonstrated that heterozygous expression of the pol δ L604G variant in mice results in normal life span and no apparent...

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Hlavní autoři: Schmitt, Michael W., Venkatesan, Ranga N., Pillaire, Marie-Jeanne, Hoffmann, Jean-Sébastien, Sidorova, Julia M., Loeb, Lawrence A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952227/
https://ncbi.nlm.nih.gov/pubmed/20628184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147017
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