Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice

Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease caused by mutations in the gene coding for the protein dystrophin. Recent work demonstrates that dystrophin is also found in the vasculature and its absence results in vascular deficiency and abnormal blood flow. This induces...

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Main Authors: Verma, Mayank, Asakura, Yoko, Hirai, Hiroyuki, Watanabe, Shuichi, Tastad, Christopher, Fong, Guo-Hua, Ema, Masatsugu, Call, Jarrod A., Lowe, Dawn A., Asakura, Atsushi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951865/
https://ncbi.nlm.nih.gov/pubmed/20705734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq334
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