ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells

The activating transcription factor 3 (ATF3) gene is induced by a variety of signals, including many of those encountered by cancer cells. We present evidence that ATF3 is induced by TGFβ in the MCF10CA1a breast cancer cells and plays an integral role for TGFβ to upregulate its target genes snail, s...

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Hlavní autoři: Yin, Xin, Wolford, Christopher C., Chang, Yi-Seok, McConoughey, Stephen J., Ramsey, Stephen A., Aderem, Alan, Hai, Tsonwin
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2010
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951469/
https://ncbi.nlm.nih.gov/pubmed/20930144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064915
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