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ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells

The activating transcription factor 3 (ATF3) gene is induced by a variety of signals, including many of those encountered by cancer cells. We present evidence that ATF3 is induced by TGFβ in the MCF10CA1a breast cancer cells and plays an integral role for TGFβ to upregulate its target genes snail, s...

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Bibliografische gegevens
Hoofdauteurs: Yin, Xin, Wolford, Christopher C., Chang, Yi-Seok, McConoughey, Stephen J., Ramsey, Stephen A., Aderem, Alan, Hai, Tsonwin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Company of Biologists 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951469/
https://ncbi.nlm.nih.gov/pubmed/20930144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064915
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