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Very Few Substitutions in a Germ Line Antibody Are Required To Initiate Significant Domain Exchange
2G12 is a broadly neutralizing anti-HIV-1 monoclonal human IgG1 antibody reactive with a high-mannose glycan cluster on the surface of glycoprotein gp120. A key feature of this very highly mutated antibody is domain exchange of the heavy-chain variable region (V(H)) with the V(H) of the adjacent Fab...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950590/ https://ncbi.nlm.nih.gov/pubmed/20702640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01111-10 |
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