A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5

CCR5 antagonists inhibit HIV entry by binding to a coreceptor and inducing changes in the extracellular loops (ECLs) of CCR5. In this study, we analyzed viruses from 11 treatment-experienced patients who experienced virologic failure on treatment regimens containing the CCR5 antagonist maraviroc (MV...

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Autores principales: Tilton, John C., Wilen, Craig B., Didigu, Chukwuka A., Sinha, Rohini, Harrison, Jessamina E., Agrawal-Gamse, Caroline, Henning, Elizabeth A., Bushman, Frederick D., Martin, Jeffrey N., Deeks, Steven G., Doms, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950574/
https://ncbi.nlm.nih.gov/pubmed/20702642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01109-10
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