Reversal of multidrug resistance by magnetic Fe(3)O(4) nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector in leukemia cells

In many instances, multidrug resistance (MDR) is mediated by increasing the expression at the cell surface of the MDR1 gene product, P-glycoprotein (P-gp), a 170-kD energy-dependent efflux pump. The aim of this study was to investigate the potential benefit of combination therapy with magnetic Fe(3)...

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Detalhes bibliográficos
Main Authors: Chen, Bao-an, Mao, Pei-pei, Cheng, Jian, Gao, Feng, Xia, Guo-hua, Xu, Wen-lin, Shen, Hui-lin, Ding, Jia-hua, Gao, Chong, Sun, Qian, Chen, Wen-ji, Chen, Ning-na, Liu, Li-jie, Li, Xiao-mao, Wang, Xue-mei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2010
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950401/
https://ncbi.nlm.nih.gov/pubmed/20957165
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