Reversal of multidrug resistance by magnetic Fe(3)O(4) nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice

In this paper we establish the xenograft leukemia model with stable multidrug resistance in nude mice and to investigate the reversal effect of 5-bromotetrandrine (5-BrTet) and magnetic nanoparticle of Fe(3)O(4) (MNP-Fe(3)O(4)) combined with daunorubicin (DNR) in vivo. Two subclones of K562 and K562...

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Autors principals: Chen, Baoan, Cheng, Jian, Wu, Yanan, Gao, Feng, Xu, Wenlin, Shen, Huilin, Ding, Jiahua, Gao, Chong, Sun, Qian, Sun, Xinchen, Cheng, Hongyan, Li, Guohong, Chen, Wenji, Chen, Ningna, Liu, Lijie, Li, Xiaomao, Wang, Xuemei
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2009
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720736/
https://ncbi.nlm.nih.gov/pubmed/19421372
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