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The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge
BACKGROUND: Cutaneous PGD2 levels increase following scratching. CRTH2 mediates chemotaxis to PGD2 and is expressed on Th2 cells and eosinophils, which infiltrate skin lesions in atopic atopic dermatitis (AD). OBJECTIVE: Examine the role of CRTH2 in a murine model of AD. METHODS: CRTH2(−/−) mice and...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950231/ https://ncbi.nlm.nih.gov/pubmed/20713302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.07.006 |
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