The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge

BACKGROUND: Cutaneous PGD2 levels increase following scratching. CRTH2 mediates chemotaxis to PGD2 and is expressed on Th2 cells and eosinophils, which infiltrate skin lesions in atopic atopic dermatitis (AD). OBJECTIVE: Examine the role of CRTH2 in a murine model of AD. METHODS: CRTH2(−/−) mice and...

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Detaylı Bibliyografya
Asıl Yazarlar: He, Rui, Oyoshi, Michiko K., Wang, James YT., Hodge, Martin R., Jin, Haoli, Geha, Raif S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950231/
https://ncbi.nlm.nih.gov/pubmed/20713302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.07.006
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