IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice

Atopic dermatitis (AD) is a common allergic inflammatory skin disease caused by a combination of intense pruritus, scratching, and epicutaneous (e.c.) sensitization with allergens. To explore the roles of IL-21 and IL-21 receptor (IL-21R) in AD, we examined skin lesions from patients with AD and use...

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Autores principales: Jin, Haoli, Oyoshi, Michiko K., Le, Yi, Bianchi, Teresa, Koduru, Suresh, Mathias, Clinton B., Kumar, Lalit, Le Bras, Séverine, Young, Deborah, Collins, Mary, Grusby, Michael J., Wenzel, Joerg, Bieber, Thomas, Boes, Marianne, Silberstein, Leslie E., Oettgen, Hans C., Geha, Raif S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613448/
https://ncbi.nlm.nih.gov/pubmed/19075398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32310
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