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Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

Understanding how protein structures and functions have diversified is a central goal in molecular evolution. Surveys of very divergent proteins from model organisms, however, are often insufficient to determine the features of ancestral proteins and to reveal the evolutionary events that yielded ex...

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Autors principals: Bridgham, Jamie T., Eick, Geeta N., Larroux, Claire, Deshpande, Kirti, Harms, Michael J., Gauthier, Marie E. A., Ortlund, Eric A., Degnan, Bernard M., Thornton, Joseph W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950128/
https://ncbi.nlm.nih.gov/pubmed/20957188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000497
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