Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts.

Pure macrophage-derived foam cells (MFC) were isolated from the aortas of rabbits made atherosclerotic by balloon deendothelialization followed by diet-induced hypercholesterolemia. The MFC were isolated under sterile conditions using an enzymatic digestion procedure and discontinuous density gradie...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Rosenfeld, M E, Khoo, J C, Miller, E, Parthasarathy, S, Palinski, W, Witztum, J L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294999/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1985115/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115006
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