Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease

AIMS: Dose modification with the anticancer agent irinotecan is recommended in patients with severe liver dysfunction. This study evaluated the impact of liver disease on the relative formation of phase I products of irinotecan biotransformation in human microsomes in vitro. METHODS: Microsomes from...

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Hauptverfasser: d'Esposito, Fabrizio, Nebot, Noelia, Edwards, Robert J, Murray, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2010
Schlagworte:
Drug Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949913/
https://ncbi.nlm.nih.gov/pubmed/20716241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03715.x
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